Probiotic formulas combining multiple species, such as ProBiota 12, are thought to provide more comprehensive support for the complex microbiome of the human gut than single-species products. Each species occupies a specific "niche," with some preferring conditions in the small intestine while others may thrive in the colon, genitourinary tract, or elsewhere in the body. While some probiotic species are known to colonize the human digestive tract, others are transient, or present in the intestines only when consumed regularly as part of the diet. ProBiota 12 includes both colonizing and transient strains, including Streptococcus thermophilus and Lactobacillus bulgaricus, which are thought to contribute to some of the health-promoting properties of cultured yogurt.
It is sometimes said that immune health begins in the gut. Special tissues in the gut make up more than 60% of the body's overall immune support. The 12 species of probiotic bacteria in ProBiota 12 produce lactic acid, hydrogen peroxide, and other fermentation products that may help support the body's natural defenses against harmful bacteria, yeast and viruses. These probiotic species may also help support the immune system by competing with unwanted or harmful bacteria for nutrients and space for colonization. They also produce short-chain fatty acids (acetate, propionate, and butyrate) that help provide nourishment for cells in the colon.
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